Special Issue: Cutting-Edge Research on Intestinal Immunity and Inflammation
نویسنده
چکیده
Research on intestinal epithelial stem cells has flourished in the last few years since their specific markers were identified. However, to exploit the potentials of those adult stem cells as a source for regenerative medicine, validation of the tissue regeneration capability of intestinal stem cells would be essential. We have recently shown that, by employing murine models of transplantation, cultured intestinal epithelial cells from the adult colon, fetal small intestine (SI), and adult SI are able to regenerate epithelia in vivo, preserving their stem cell properties. These data provide the evidence that multiple types of intestinal cells could be the source for the stem cell therapy for intestinal diseases in humans. Rec.9/7/2014, Acc.9/16/2014, pp19-22 Correspondence should be addressed to: Tetsuya Nakamura, Department of Advanced Therapeutics for GI Diseases, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Phone: +81-3-5803-5877, Fax: +81-3-5803-0268, E-mail: [email protected]
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